A novel electrochemical sensor based on metal nanoparticles and molecularly imprinted polymer nanocomposite with biological applications

Metal nanoparticles trapped in a biopolymer composite due to electrical conductivity properties improve electrochemical sensors with biomedical and environmental applications. The study aims are design novel molecularly imprinted polymer (MIP) based on magnetic graphene oxide (Fe3O4@GO) modified silica (SiO2) gold (AuNPs) detect serotonin (5-hydroxytryptamine, 5-HT). A suitable amount of 5-HT is effective motivational functions the environment because it serotonergic neurotransmitter. But desired nanocomposite may have relatively low recognition, therefore must be choosing type functional monomer careful. In this regard, sensor began by synthesis Fe3O4@GO-SiO2@AuNPs nanocomposite. Then, MIP electropolymerization was carried out using p-aminothiophenol (PATP)-functionalized presence 5HT as template molecule. Electrochemical polymerization developed cyclic voltammetry (CV) were studied use differential pulse (DPV) technology solution. After optimization preparation measurement conditions designed sensor, concentration range 0.1 μM 10 linearly, detection limit 1 × 10-5 (S / N = 3). wide presented metal functionalized appropriate great effect performance sensor. Furthermore, PATP-functionalized increase recognition prepared quantification biological samples high selectivity recovery.